Overcoming mechanisms of resistance to anti-angiogenic treatments targeting the VEGF system

DescriptionThe outline of this LITERATURE project is to evaluate aspect of the mechanisms to resistance of anti-VEGF therapy. More details can be seen in the Project Description word document. This is an order for “literature analysis” and “conclusions and future directions” section
My aim is to find the role of FGF2 or bFGF in acquired resistance upon anti-VEGF therapy in cancer. The literature analysis is worth 3250 words (possibly 3-4 key papers) and the Conclusions and Future directions is worth 750 words. Total is 4000 words not including references and figure/table legends with 500-675 words to spare for figure/table legends (Add in key or important figures/table from the study!)
I have not thought what paper to critically analyse on. However, I have added a review article “role of bFGF in acquired resistance…” in the attached files below, so you can take a pick of which study do you recommend to take and why or just scroll the web for more articles. Exclusion criteria of the key paper should be peer reviewed and after 2016. Any other background and supplementary papers should be after 2000.
No introduction as it has been taken care of, so you can start off with “In this study: ….. by Holmes et al. (2020).” If possible, write why did you pick this paper compared to other papers in publication. Then analyse the results with some figures and figure legend and discuss the limitations and conclusions of the study. Finally add in conclusions and future directions section. More details on what format I would like the literature analysis to be is on the “Literature Analysis Example” word doc below.
Other reviews and articles you can consider to look at is attached as well. Aim for 30-35 references.

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