Write an account on the use of IR spectroscopy in the identification drug substances by the European Pharmacopoeia, including potential polymorphic forms.
Describe in your own words the principles, applications and limitations of the Karl Fischer titration. Max two pages – must be illustrated with chemistry equations and drawings as appropriate.
Discuss the various methods of analysis that may be used to characterise the physical/solid state properties of components of a tablet formulation (active pharmaceutical ingredients and excipients).
Why are powder flow properties important in the manufacture of pharmaceuticals? Discuss the factors which influence the flow properties of a pharmaceutical powder or granulate.
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